Repositório Colecção: Artigos em Acta de Conferência Internacional (ESS)
http://hdl.handle.net/10314/587
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Sentido de coerência e desempenho académico no ensino superior: uma revisão sistemática da literatura
http://hdl.handle.net/10314/3988
Título: Sentido de coerência e desempenho académico no ensino superior: uma revisão sistemática da literatura
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<br/>Autor: Carrondo, E.
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Therapy adherence of out patients in the pharmacy services of a hospital unit
http://hdl.handle.net/10314/3464
Título: Therapy adherence of out patients in the pharmacy services of a hospital unit
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<br/>Autor: Rodrigues, Diana; Marante, Nídia; Silva, Pedro; Carvalho, Sara; Araújo, André; Ribeiro, Maximiano; Coutinho, Paula; Ventura, Sandra; Roque, Fátima
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<br/>Resumo: The low adherence to therapy of chronic patients undergoing long-term treatment has been identified as a major factor responsible for the lack of effectiveness of prescribed treatments.
In the present study, we have conducted interviews to patients over the age of 18 that acquired their medications in a hospital pharmacy of the north region of Portugal. Compliance with the treatment regimen and self-perception of health status were assessed by applying the Morisky Medication Adherence Scale© (MMA-8-Item) and the The Brief Illness Perception Questionnaire© (IPQ-B), respectively.
The association between gender and some types of disease was observed for Psoriatic Arthritis and for the incidence of breast cancer in women and lung cancer in males. Of the 11 patients, 3 reported to have undergo therapeutic changes from the beginning of treatment.
These three correspond to patients with Hepatitis B and Psoriatic Arthritis.
The results of therapy adherence show 90.9 % of adherence, in which 5 of the 11 respondents showed a high degree of adherence to therapy and only 1 revealed lower levels of adherence. According
to the MMA-8-Item (n = 11) respondents do not associate the nonadherence to oblivion of taking the medicines. However, the limiting factors of adherence most mentioned were adverse effects associated with the medication and depressive states linked with the negative impact that the disease has on society.
Although this is a pilot study, our results have shown to be promising.
Patients reported high adherence rates and it was verified a relationship between therapy adherence and the self-perception of health.
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Thermal therapy in health: Categorization of therapeutic indications for natural mineral waters in the region of Beira interior of Portugal
http://hdl.handle.net/10314/3335
Título: Thermal therapy in health: Categorization of therapeutic indications for natural mineral waters in the region of Beira interior of Portugal
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<br/>Autor: Araújo, André; Coutinho, Paula
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<br/>Resumo: Portugal is one of Europe's richest countries in thermal waters [1], and the majority of Portuguese thermal resorts are distributed by northern and central regions.
The thermalism comprises the use of natural mineral water and other complementary means for prevention, treatment, rehabilitation or wellness [2]. The use of such water, also known as mineral-medicinal water, for therapeutic purposes has always been aroused a continuous interest in carrying out the characterization of this type of waters and the establishment of an eventual relationship for the treatment of a specific pathological condition. Thermal waters can be defined by waters from the subsoil, which are generated in specific geologic conditions and presenting "physico-chemical dynamism" [3,4]. Thermal mineral water has three fundamental characteristics:
it originates naturally from the earth, it is bacteriologically pure and has therapeutic potential [3,4]. Most thermal waters are originated from the water resulting from precipitation, and with its infiltration in depth, they acquire particular physico-chemical characteristics, depending on the mineralogical composition of the geological formations through the water flows [1]. In fact, the geological variability in Portugal enables the occurrence of thermal waters with a high diversity in terms of physico-chemical composition [4].
Thermal waters are classified according to parameters such as temperature, osmotic pressure, radioactivity, chemical composition and mineralisation, being the latter two considered of greater importance [5].
The various therapeutic effects described with thermal therapy have been attributed to its physico-chemical composition, being classified as bicarbonated, sulfated, chlorided, sulphurous, hiposaline and gasocarbonic waters, and this correlation has been the basis for the indication of the different thermal resorts for different disorders of several vital systems of the body, and it is precisely in this context that the existing data are more controversial. From a simplistic and reductionist point of view, most Portuguese thermal waters are described as weakly mineralized, sulphurous, bicarbonated or chlorinated and sodium type waters.
In the present work, a literature review was undertaken in order to create an index of information of physico-chemical composition of thermal waters of the Beira Interior region and its therapeutic indications, followed by an exhaustive statistical analysis to assess the correlation between the different physico-chemical parameters and the therapeutic indications described for that thermal waters.
The results obtained allow us to demonstrate the role of the major components of the thermal waters to a particular therapeutic effect and hence to create a useful tool for regional typology of the thermal waters in Portugal as a valuable alternative of the therapeutic armamentarium for well and specific-oriented pathological disturbs.
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Development and validation of an analytical methodology for the determination of antipsychotic drugs in hospital wastewaters by gas chromatography–tandem mass spectrometry (GC–MS/MS)
http://hdl.handle.net/10314/3258
Título: Development and validation of an analytical methodology for the determination of antipsychotic drugs in hospital wastewaters by gas chromatography–tandem mass spectrometry (GC–MS/MS)
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<br/>Autor: Logarinho, F.; Rosado, T.; Lourenço, C.; Araújo, André
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<br/>Resumo: The consumption of psychiatric drugs has seen a huge increase during the last years as a consequence of the financial European crisis, and this can lead to psychological health effects causing several psychiatric diseases. These drugs have become pseudo-persistent in the environment due to their large volumes of use, and nowadays they are considered environmental emerging contaminants.
Within this main group, the antipsychotic class have experienced an expressive increase in consumption, namely in Portugal, being used for the management of psychotic episodes as well as for other related behavioral symptoms and even other therapeutic indications.
The present work describes the development and validation of a highly sensitive analytical method for the simultaneous determination of antipsychotic drugs in influent and effluent hospital wastewaters by GC–MS/MS. The studied compounds were levomepromazine, clozapine, chlorpromazine, haloperidol, quetiapine and ciamemazine using promazine as internal standard. Sample preparation was carried out by solid phase extraction (SPE) using mixed mode-columns (Strata XC – 200 mg) and followed by derivatization of the extracts with MSTFA (with TMCS). Chromatographic separation was achieved on a 5% phenylmethylsiloxane column. All chromatographic conditions and mass spectrometric parameters were previously optimized to enhance the maximum signal. The method was validated following internationally accepted criteria, and the studied parameters included selectivity, linearity, limits of detection (LOD) and quantification (LOQ), instrumental limits, precision and accuracy, stability and recovery. The procedure was linear for concentrations ranging from 0.1 to 10 g/L (0.02–2 g/L for haloperidol), with determination coefficients higher than 0.99 for all analytes. Intra- and inter-day precision was lower than 15% for all analytes at the studied concentrations, while accuracy remained between a ±15% interval. Recoveries ranged from 35% to 80%. Low LODs were achieved, between 2 and 10 pg/mL, allowing a reliable and accurate quantification of the analytes at trace level (low ppb). All studied parameters complied with the defined criteria and the method enabled the successful determination of antipsychotics in hospital wastewater samples.