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Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10314/3145
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| Título: | Use of off-label and unlicenced drugs in hospitalised paediatric patients: a systematic review |
| Autores: | Magalhães, Jona
Teixeira Rodrigues, António
Roque, Fátima
Figueiras A, Adolfo
Falcão, Amilcar
Herdeiro, Maria Teresa |
| Palavras Chave: | Paediatric
Unlicensed
Off-label
Drug
Hospital care |
| Data: | Jan-2015 |
| Editora: | Europen Journal of Clinical Pharmacology (Springer) |
| Resumo: | PURPOSE:
The aim of this review is to assess the extent of the use of off-label and/or unlicenced drugs among hospitalised children.
METHODS:
A systematic search was made in MEDLINE-PubMED for papers published from 1994 to 2012, addressing the prescription of off-label and/or unlicenced drugs for the paediatric population in hospital care.
RESULTS:
Of the 829 studies retrieved, 34 met the inclusion criteria. Prescriptions ranged from 12.2 to 70.6 % for off-label and from 0.2 to 47.9 % for unlicensed drugs. The percentage of children who received at least one off-label and/or unlicensed drug ranged from 42.0 to 100 %, with newborns being the population that received most of such drugs. Off-label prescriptions were essential for dose modification (7.1-73.1 %) and unlicensed prescriptions for formulation modification purposes (3.6-100 %).
CONCLUSIONS:
These findings show that: (i) off-label and/or an unlicensed prescribing is widespread among the hospitalised paediatric population worldwide, (ii) there is no consensus on a definition of off-label and/or unlicensed drugs and (iii) preterm newborns receive most off-label and/or unlicensed drugs. By shedding new light on off-label and/or unlicensed drug prescribing, these findings will hopefully contribute to generating new, more effective knowledge about the paediatric population's need for quality drugs that are both safe and efficacious. |
| URI: | http://hdl.handle.net/10314/3145 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
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Ficheiros deste Registo:
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Descrição |
Tamanho | Formato |
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| Use of off-label and unlicenced drugs in hospitalised paediatric.pdf | | 753Kb | Adobe PDF | Ver/Abrir | |
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