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http://hdl.handle.net/10314/3502
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| Título: | IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion. |
| Autores: | Correia, Margareta P.
Costa, Alexandra V.
Uhrberg, Markus
Cardoso, Elsa M.
Arosa, Fernando A. |
| Palavras Chave: | CD8+ T cells
Cytokines
Differentiation
IL-15 |
| Data: | Sep-2010 |
| Editora: | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Citação: | Immunobiology. 2011 May;216(5):604-12. |
| Resumo: | During the last years several authors have described a small population of CD8+ T cells expressing NK receptors (NKRs). Although their origin remains largely unknown, we have recently demonstrated that IL-15 is capable of inducing NKR expression in purified human CD8+CD56- T cells. In this study we show that IL-15-driven NKR induction in CD8+ T cells was linked with CD56 de novo acquisition, consistent with an effector-memory phenotype, increased anti-apoptotic levels, high granzyme B/perforin expression and with the ability of displaying in vitro NK-like cytotoxicity. Interestingly, dissection of NKR functional outcome in IL-15-cultured CD8+ T cells revealed: (i) that NKG2D cross-linking was able per se to upregulate degranulation levels and (ii) that KIR and NKG2A cross-linking upregulated secretion of cytokines such as IFN-γ, TNF-α, IL-1β and IL-10. These results suggest that IL-15 is capable of differentiating CD8+ T cells into NK-like T cells displaying a regulatory phenotype. |
| URI: | http://hdl.handle.net/10314/3502 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
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Ficheiros deste Registo:
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| S0171298510001798[1] | | 49Kb | HTML | Ver/Abrir | |
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