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|Título: ||IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion.|
|Autores: ||Correia, Margareta P.|
Costa, Alexandra V.
Cardoso, Elsa M.
Arosa, Fernando A.
|Palavras Chave: ||CD8+ T cells|
|Data: ||Sep-2010 |
|Editora: ||ELSEVIER GMBH, URBAN & FISCHER VERLAG|
|Citação: ||Immunobiology. 2011 May;216(5):604-12.|
|Resumo: ||During the last years several authors have described a small population of CD8+ T cells expressing NK receptors (NKRs). Although their origin remains largely unknown, we have recently demonstrated that IL-15 is capable of inducing NKR expression in purified human CD8+CD56- T cells. In this study we show that IL-15-driven NKR induction in CD8+ T cells was linked with CD56 de novo acquisition, consistent with an effector-memory phenotype, increased anti-apoptotic levels, high granzyme B/perforin expression and with the ability of displaying in vitro NK-like cytotoxicity. Interestingly, dissection of NKR functional outcome in IL-15-cultured CD8+ T cells revealed: (i) that NKG2D cross-linking was able per se to upregulate degranulation levels and (ii) that KIR and NKG2A cross-linking upregulated secretion of cytokines such as IFN-γ, TNF-α, IL-1β and IL-10. These results suggest that IL-15 is capable of differentiating CD8+ T cells into NK-like T cells displaying a regulatory phenotype.|
|Aparece nas Colecções:||Artigos em Revista Internacional (ESS)|
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