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http://hdl.handle.net/10314/3503
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| Título: | Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8+ T Cell Differentiation |
| Autores: | Correia, Margareta P.
Cardoso, Elsa M.
Pereira, Carlos F.
Neves, Rui
Uhrberg, Markus
Arosa, Fernando A. |
| Data: | 15-May-2009 |
| Editora: | AMER ASSOC IMMUNOLOGISTS |
| Citação: | J Immunol. 2009 May 15;182(10):6149-59 |
| Resumo: | Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing NKR. Although the origin of this population remains controversial, it is possible to speculate that the hepatic microenvironment, namely epithelial cells or the cytokine milieu, may play a role in its shaping. IL-15 is constitutively expressed in the liver and has a key role in activation and survival of innate and tissue-associated immune cells. In this in vitro study, we examined whether hepatocyte cell lines and/or IL-15 could play a role in the generation of NK-like T cells. The results show that both HepG2 cells and a human immortalized hepatocyte cell line increase survival and drive basal proliferation of T cells. In addition, IL-15 was capable of inducing Ag-independent up-regulation of NKR, including NKG2A, Ig-like receptors, and de novo expression of CD56 and NKp46 in CD8(+)CD56(-) T cells. In conclusion, our study suggests that hepatocytes and IL-15 create a favorable microenvironment for T cells to growth and survive. It can be proposed that the increased percentage of intrahepatic nonclassical NKT cells could be in part due to a local CD8(+) T cell differentiation. |
| URI: | http://hdl.handle.net/10314/3503 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
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| Correia et al_2009.pdf | | 843Kb | Adobe PDF | Ver/Abrir | |
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