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http://hdl.handle.net/10314/3507
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| Título: | A study of some hepatic immunological markers, iron load and virus genotype in chronic hepatitis C. |
| Autores: | Cardoso, Elsa M.
Duarte, Miguel A.
Ribeiro, Eduarda
Rodrigues, Pedro
Hultcrantz, Rolf
Sampaio, Paula
Ehrlich, Rachel
Carvalho, João
Fraga, José
de Sousa, Maria |
| Palavras Chave: | HFE
MHC-I
IFN
Hepatitis C virus
Liver |
| Data: | Aug-2004 |
| Editora: | ELSEVIER SCIENCE BV |
| Citação: | J Hepatol. 2004 Aug;41(2):319-26. |
| Resumo: | BACKGROUND/AIMS:
Host factors that may influence progression of hepatitis C infection to chronic hepatitis include T-cell responses and iron accumulation. We evaluated the hepatic expression of immunological markers relevant for a cytotoxic response in relation to viral and HFE genotype.
METHODS:
Frozen liver biopsies were obtained at diagnosis from 28 HFE genotyped patients. Sections stained for CD8, MHC-I, beta(2)m, HFE and CD68 were analyzed blind by morphometry. Response to therapy was available in 12 cases.
RESULTS:
A negative correlation was found between the number of CD8(+) cells and fibrosis. CD8(+) cells localized as clusters in portal tracts and sinusoids and were seen interacting with MHC-I positive lining cells. MHC-I and beta(2)m were expressed mainly in the endothelial and Kupffer cells. HFE was expressed in most, but not all, round and dendritic CD68(+) cells. Patients with virus genotype 3a had higher hepatic MHC-I and HFE expression, and a better-sustained response to IFN therapy than other patients.
CONCLUSIONS:
In chronic hepatitis C virus infection MHC-I expression in the liver seems to relate to viral-genotype. In addition, the expression of MHC-I molecules by Kupffer cells places them as probable important players in the host response to HCV. |
| URI: | http://hdl.handle.net/10314/3507 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
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Ficheiros deste Registo:
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Descrição |
Tamanho | Formato |
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| Cardoso et al 2004.pdf | | 289Kb | Adobe PDF | Ver/Abrir | |
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