|
Biblioteca Digital do IPG >
Escola Superior de Saúde (ESS) >
Artigos em Revista Internacional (ESS) >
Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10314/3508
|
| Título: | Increased hepatic iron in mice lacking classical MHC class I molecules. |
| Autores: | Cardoso, Elsa M.
Macedo, Maria G.
Rohrlich, Pierre
Ribeiro, Eduarda
Silva, Manuel T.
Lemonnier, François A.
de Sousa, Maria |
| Data: | 8-Aug-2002 |
| Editora: | AMER SOC HEMATOLOGY |
| Citação: | Blood. 2002 Dec 1;100(12):4239-41. |
| Resumo: | Iron accumulation in the liver in hereditary hemochromatosis (HH) has been shown to be highly variable. Some studies point to the importance of major histocompatibility complex (MHC) class I (MHC-I) and CD8(+) cells as modifiers of iron overload. In this report, using mice knockout for H2K(b-/-) and H2D(b-/-) genes, it is demonstrated that lack of classical MHC-I molecules results in a spontaneous increase of nonheme iron content in the liver (mainly located in the hepatocytes) when compared to wild-type mice. In CD8(-/-) and Rag2(-/-) mice, no spontaneous hepatic iron accumulation was observed. These results demonstrate for the first time that classical MHC-I molecules could be involved in the regulation of iron metabolism and contribute to the established genotype/phenotype discrepancies seen in HH. |
| URI: | http://hdl.handle.net/10314/3508 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
|
Ficheiros deste Registo:
| Ficheiro |
Descrição |
Tamanho | Formato |
|---|
| Cardoso EM_Blood_2002.pdf | | 265Kb | Adobe PDF | Ver/Abrir | |
|
|
