Biblioteca Digital do IPG >
Escola Superior de Saúde (ESS) >
Artigos em Revista Internacional (ESS) >
Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10314/3720
|
Título: | Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats |
Autores: | Ferreira, Ana Rodrigues, Márcio Marques, Alexandre Falcão, Amílcar Alves, Gilberto |
Palavras Chave: | (-)-Epigallocatechin gallate Licarbazepine Oxcarbazepine P-glycoprotein Pharmacokinetics Silymarin |
Data: | 2017 |
Relatório da Série N.º: | Volume 106, Part A, Pages 446-454 |
Resumo: | Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)–mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC). Rats were pre-treated intraperitoneally with silymarin (25 mg/kg), EPG (25 mg/kg), silymarin/EPG (12.5/12.5 mg/kg; 6.25/18.75 mg/kg; 18.75/6.25 mg/kg) or verapamil (25 mg/kg, reference P-gp inhibitor) before the intraperitoneal administration of OXC (50 mg/kg). Pre-treatment with dual silymarin/EPG combinations originated peak plasma concentrations of OXC and LIC (pharmacologically active metabolite of OXC) similar to those achieved in the presence of verapamil (positive control). Moreover, the effects promoted by silymarin/EPG combinations on the magnitude of systemic drug exposure to OXC and LIC were also reflected in the corresponding drug levels attained in the brain (biophase). These findings evidence the synergistic effect of silymarin and EPG in enhancing the degree of systemic exposure to OXC and LIC in rats, which occurred in a comparable extent to that observed with verapamil. Hence, our findings support the combination of flavonoid-type P-gp inhibitors and P-gp substrate antiepileptic drugs as a potential therapeutic strategy for the management of pharmacoresistant epilepsy. |
URI: | http://hdl.handle.net/10314/3720 |
Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
|
Ficheiros deste Registo:
Ficheiro |
Descrição |
Tamanho | Formato |
Ferreira et al 2017 artigo.pdf | | 273Kb | Adobe PDF | Ver/Abrir | |
|
|