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Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10314/3974
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| Título: | Anti-inflamatório choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters |
| Autores: | Azevedo, Ana
Costa, Susana
Dias, Ana
Marques, Alexandre
Pinto, Paula
Bica, Katharina
Ressmann, Anna
Passos, Marieta
Pereira, André
Reis, Salette
Saraiva, M. Lúcia |
| Palavras Chave: | Non-steroidal anti-inflammatory drugs Ionic liquids Partition coefficient Shake flask method Cytochrome c oxidase |
| Data: | 9-Feb-2017 |
| Editora: | Journal of Molecular Liquids |
| Resumo: | The impact on in vivo efficacy and safety of two novel ionic liquids based on the association of choline with nonsteroidal
anti-inflammatory drugs, ketoprofen and naproxen forming IL-APIs, was evaluated. Their lipophilicity,
solubility and toxicity were assessed aiming the illustration of the pharmaceutical profile and potential toxic
impact.
Partition coefficientwas determined usingmicelles of hexadecylphosphocholine and UV–Vis derivative spectroscopy.
Additionally, solubility in phosphate buffer pH 7.4 wasmeasured using amodified shake flaskmethod and
UV–Vis spectroscopy as detection technique. Ultimately, toxicity was considered resorting to a fully automated
cytochrome c oxidase assay based onmicrofluidics. The obtained results demonstrated that the IL-APIs' drug format
has the ability to interact with biological membranes and also improves solubility up to 58 times. Moreover,
it was evidenced that, although being a nutrient, choline influences the IL-APIs' toxicity. The studied anti-inflammatory
IL-APIs exhibited promising properties regarding their incorporation in pharmaceutical formulations. |
| URI: | http://hdl.handle.net/10314/3974 |
| ISSN: | doi.org/10.1016/j.molliq.2017.02.027 |
| Aparece nas Colecções: | Artigos em Revista Internacional (ESS)
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Ficheiros deste Registo:
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| AndréA-94_a.pdf | | 443Kb | Adobe PDF | Ver/Abrir | |
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